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Mahmoud Rouabhia

docteur Rouabhia

Professeur titulaire
Discipline : immunologie buccale et pathologie buccales, biomatériaux

Pavillon de médecine dentaire, local 1728
418 656-2131, poste 416321

Formation universitaire

Post doctorat en Immunologie/inflammation, Dalhousie University Canada 1989
Doctorat en Immuno-physiologie Faculté des sciences, Université de Limoges, France 1988
Maîtrise en biologie cellulaire et moléculaire Faculté des sciences, Université de Limoges, France 1985
Maîtrise en biologie cellulaire et moléculaire Faculté des sciences, Université de Limoges, France

Spécialité clinique et projets de recherche

  • Investigate C. albicans and S. mutans passage through the EHOM following treatment with two Oasis products
  • Étudier le lien entre la fumée de cigarette et le cancer buccal
  • Electrically conductive biodegradable polymers for tissue engineering
  • Effet de la stimulation électrique sur la cicatrisation
  • Évaluer l’effet de la fumée de cigarette sur la croissance des cellules gingivales
  • Étudier l’effet des facteurs de croissance sur la régénération osseuse in vitro
  • Étudier les interactions entre l’hôte et les microorganismes
  • Identification of early phase C. albicans biofilm proteins
  • Efficacité d’un nouveau peptide anti-microbien sur la virulence de Candida albicans

Publications récentes (5 dernières années)

  1. Almutairi MH, Al-Numair NS, Parine NR, Almutairi BO, Alrefaei AF, Rouabhia M, Semlali A. (2021) “The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.” Saudi Journal of Biological Sciences, Vol. 28 (No. 7), Pages 3972-3980. https://doi.org/10.1016/j.sjbs.2021.04.011
  2. Semlali A, Almutairi MH, Alharbi SN, Alamri AM, Alrefaei AF, Almutairi BO, Rouabhia M. (2021) “The correlation between single nucleotide polymorphisms of the thymic stromal lymphopoietin receptor and breast cancer in a cohort of female patients in Saudi Arabia.” Environmental Acience and Pollution Research, Vol. 2021.
  3. Abedin-Do A, Zhang Z, Douville Y, Méthot M, Rouabhia M. (2021) “Effect of Electrical Stimulation on Diabetic Human Skin Fibroblast Growth and the Secretion of Cytokines and Growth Factors Involved in Wound Healing.” Biology. Vol. 10. (No.7), Page 641. https://doi.org/10.3390/biology10070641
  4. Rouabhia M, Semlali A. (2021) “Electronic cigarette vapor increases Streptococcus mutans growth, adhesion, biofilm formation, and expression of the biofilm-associated genes.” Oral Diseases, Vol. 27. (No. 3), Pages 639-647. https://doi.org/10.1111/odi.13564
  5. Samot J, Rouabhia M. (2021) “Effect of Dermaseptin S4 on C. albicans Growth and EAP1 and HWP1 Gene Expression.” Probiotics Antimicrobial Proteins, Vol. 13. (No. 1). Pages 287-298. DOI:10.1007/s12602-020-09685-0, https://link.springer.com/article/10.1007%2Fs12602-020-09685-0
  6. Benzaid C, Belmadani A, Tichati L, Djeribi R, Rouabhia M. (2021) “Effect of L. Essential Oil on Growth, Biofilm Formation and Virulent Genes Expression.” Antibiotics , Vol. 10. (No. 1). https://doi.org/10.3390/antibiotics10010054
  7. Contant C, Rouabhia M, Loubaki L, Chandad F, Semlali A. (2021) ”Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways.” Scientific Report, Vol. 11. https://doi.org/10.1038/s41598-021-92456-w
  8. Almutairi M, Rouabhia M, Sahab Almutairi M, Al-Zahrani M, Al-Numair NS, Mohammad Alhadeq A, Reddy Parine N, Semlali A. (2021) “Correlation between genetic variation in thymine DNA glycosylase and smoking behavior.” Gene, Vol. 766. (No. Janv. 2021). https://doi.org/10.1016/j.gene.2020.145092
  9. Semlali A, Beji S, Ajala I, Rouabhia M. (2021) “Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage.” Archives of Oral Biology, Vol. 129 , (No. sept 2021). https://doi.org/10.1016/j.archoralbio.2021.105200
  10. Rouabhia M, Piche M, Corriveau MN, Chakir J. (2020) “Effect of e-cigarettes on nasal epithelial cell growth, Ki67 expression, and pro-inflammatory cytokine secretion.” American Journal of Otolarungology.  Vol. 41. (No. 6). https://doi.org/10.1016/j.amjoto.2020.102686
  11. Rouabhia M, Park HJ, Douville Y, Methot M, Zhang Z, Abedin-Do A. (2020) “Electrical stimulation promotes the proliferation of human keratinocytes, increases the production of keratin 5 and 14, and increases the phosphorylation of ERK1/2 and p38 MAP kinases.”  Journal of Tissue Engineering and Regenerative Medicine. Vol. 14. (No. 7). Pages 909-919. https://doi.org/10.1002/term.3040
  12. Rouabhia M.  (2020) “Impact of Electronic Cigarettes on Oral Health: a Review.” Journal (Canadian Dental Association), 86:k7. https://doi.org/10.1080/10408444.2020.1713726
  13. Semlali A, Almutairi M, Pathan AAK, Azzi A, Parine NR, AlAmri A, Arafah M, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Alanazi M, Rouabhia M. (2019) “Toll-like receptor 6 expression, sequence variants, and their association with colorectal cancer risk.”  Journal of Cancer, Vol. 10. (No. 13). ISSN: 1837-9664.  https://www.jcancer.org/v10p2969.htm
  14. Ouartsi N, Djeribi R, Boukachabia A, Menaa F, Gasmi K, Akacem D, Rouabhia M. (2019) “In vitro Biodegradation of Gliclazide by Aeromonas hydrophila and Serratia odorifera Bacteria.” Environmental Engineering Science. Vol. 36. (No. 6). Pages 643-649. https://doi.org/10.1089/ees.2018.0224
  15. Benzaid C, Belmadani A, Djeribi R, Rouabhia M. (2019) “The Effects of Mentha × piperita Essential Oil on Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes.”  Antibiotics. Vol. 8. (No. 1). Page 10. https://doi.org/10.3390/antibiotics8010010
  16. Benzaid C, Tichati L, Djeribi R, Rouabhia M. (2019) “Evaluation of the Chemical Composition, the Antioxidant and Antimicrobial Activities of Mentha × piperita Essential Oil against Microbial Growth and Biofilm Formation.” Journal of Essential Oil Bearing Plants. Vol. 22-2019. (No. 2). Pages 335-346. https://doi.org/10.1080/0972060X.2019.1622456
  17. Mao J, Rouabhia M and Zhang Z. (2019). “Surface modification by assembling: a modular approach based on the match in nanostructures. Journal of Materials Chemistry B.  (No. 5). Pages 755-762. http://dx.doi.org.acces.bibl.ulaval.ca/10.1039/C8TB02789G. https://doi.org/10.1039/C8TB02789G
  18. Alanazi H, Semlali A, Chmielewski W, Rouabhia M. (2019). “E-Cigarettes Increase Candida albicans Growth and Modulate its Interaction with Gingival Epithelial Cells.” International Journal of Environmental Research and Public Health . Vol. 16. (No. 2).  Page 294. https://doi.org/10.3390/ijerph16020294
  19. Benzaid C, Belmadani A, Djeribi R and Rouabhia M. (2019). “The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes.” Antibiotics, Vol. 8 (No. 1, 2019), page 10. https://doi.org/10.3390/antibiotics8010010.
  20. Rouabhia M, Mighri N, Mao J, Park H-J*, Mighri F, Ajji A, Zhang Z. (2018). “Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation.” Canadian Journal of Chemical Engineering. Vol. 96. (No. 10). Pages 2236-2242. https://doi.org/10.1002/cjce.23205
  21. Semlali A, Almutairi M, Rouabhia M, Reddy Parine N, Al Amri A, S Al-Numair N, M Hawsawi Y, Saud Alanazi M. (2018) “Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population.” PLoS One. 2018 Nov 2; vol. 13 (No. 11):e0203376. https://doi.org/10.1371/journal.pone.0203376
  22. Rouabhia M, Alanazi H, Park HJ, Gonçalves RB. (2018). “Cigarette smoke and e-cigarette vapor dysregulate osteoblast interaction with titanium dental implant surface.” Journal of Oral Implantology.  Vol. 45, (No. 1, février 2019). Pages 2-11.  https://doi.org/10.1563/aaid-joi-D-18-00009
  23. Alanazi H, Park HJ, Chakir J, Semlali A, Rouabhia M. (2018) “Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis.” Food and Chemical Toxicology. Vol. 118. (No. Août 2018) pages 154-167.  https://doi.org/10.1016/j.fct.2018.05.005
  24. Belmadani A, Semlali A, Rouabhia M. (2018). “Dermaseptin-S1 decreases Candida albicans growth, biofilm formation and the expression of hyphal wall protein 1 and aspartic protease genes.” Journal of Applied Microbiology. Vol. 125 (No. 1), pages 72-83, ISSN: 1364-5072. https://doi.org/10.1111/jam.13745
  25. Salem IH, Plante S, Gounni AS, Rouabhia M, Chakir J. (2018), “A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process.” Cellular Signaling, Vol. 43, (No. mars 2018) pages 47-54 ISSN: 0898-6568. https://doi.org/10.1016/j.cellsig.2017.12.001
  26. Haj-Salem I, Plante S, Gounni AS, Rouabhia M, Chakir J. (2018). “Fibroblast-derived exosomes promote epithelial cell proliferation through TGF-β2 signalling pathway in severe asthma.” Allergy; European journal of allergy and clinical immunology, Vol.73 (No. 1), p. 178-186. https://doi.org/10.1111/all.13234
  27. Mao J, Li C, Park HJ, Rouabhia M, Zhang Z. (2017) “Conductive Polymer Waving in Liquid Nitrogen.” ACS Nano. Vol. 11, (No. 10), pages 10409-10416. https://doi.org/10.1021/acsnano.7b05546
  28. Rouabhia M, Rouabhia D, Park HJ, Giasson L, Zhang Z. (2017) “Effect of soft foods on primary human gingival epithelial cell growth and the wound healing process.” Food Research International. Vol. 100, (partie 1), pages 433-441. https://doi.org/10.1016/j.foodres.2017.07.041
  29. Park HJ, Salem M, Semlali A, Leung KP, Rouabhia M. (2017) “Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro.” Peptides. Vol. 93, pages 33-43. https://doi.org/10.1016/j.peptides.2017.05.003
  30. Rouabhia M, Park HJ, Semlali A, Zakrzewski A, Chmielewski W, Chakir J. (2017) “E-cigarette vapor induces an apoptotic response in human gingival epithelial cells through the caspase-3 pathway.” Journal of Cellular Physiology, Vol. 232, (No. 6), pages 1539‑1547. https://doi.org/10.1002/jcp.25677
  31. Wang Y, Rouabhia M, Lavertu D, Zhang Z. (2017) “Pulsed electrical stimulation modulates fibroblasts’ behavior through the Smad signalling pathway.” Journal of Tissue Engineering and Regenerative Mededecine. Vol. 11, (No. 4), pages 1110‑1121. https://doi.org/10.1002/term.2014
  32. Semlali A, Parine NR, Al Amri A, Azzi A, Arafah M, Kohailan M, Shaik JP, Almadi MA, Aljebreen AM, Alharbi O, Ali Azzam N, Rouabhia M, Alanazi MS. (2017) “Association between TLR-9 polymorphisms and colon cancer susceptibility in Saudi Arabian female patients.” Onco Targets and Therapy. Vol. 2017, (No. 10), pages 1‑11. https://doi.org/10.2147/OTT.S106024
  33. Kohailan M, Alanazi M, Rouabhia M, Al Amri A, Parine NR, Semlali A. (2017) “Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia.” Onco Targets and Therapy. Vol. 2017, (No. 10), pages 745-752. https://doi.org/10.2147/OTT.S111971
  34. Semlali A, Jalouli M, Parine NR, Al Amri A, Arafah M, Al Naeem A, Abdullah Ajaj S, Rouabhia M, Alanazi MS. (2017) “Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women.” Onco Targets and Therapy.  Vol. 2017, (No. 10), pages 1207-1216. https://doi.org/10.2147/OTT.S112165
  35. Semlali A, Almutairi M, Parine NR, Al Amri A, Shaik JP, Al Naeem A, Abdulla Ajaj S, Rouabhia M, Alanazi MS. (2017) “No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.” Onco Targets and Therapy. Vol. 2017, (No. 10), pages 2325-2333. https://doi.org/10.2147/OTT.S121618
  36. Bakopoulou A, Huang GT, Rouabhia M, Geurtsen W, About I. (2017) “Advances and New Technologies towards Clinical Application of Oral Stem Cells and Their Secretome.” Stem Cells International, Vol. 2017, Article ID 6367375, https://doi.org/10.1155/2017/6367375
  37. Wang Y, Rouabhia M, Zhang Z (2016). “Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGFβ1/ERK/NF-κB axis.” Biochim Biophys Acta – General Subjects.  Vol. 1860, (No. 7), Pages 1551-1559. https://doi.org/10.1016/j.bbagen.2016.03.023
  38. Semlali A, Parine NR, Al Amri A, Azzi A, Arafah M, Kohailan M, Shaik JP, Almadi MA, Aljebreen AM, Alharbi O, Ali Azzam N, Rouabhia M, Alanazi MS. (2016) “Association between TLR-9 polumorphisms and colon cancer susceptibility in Saudi Arabian female patients.” Onco Targets and Therapy.  Vol. 10, pages 1-11. https://doi.org/10.2147/OTT.S106024
  39. Kohailan M, Alanazi M, Rouabhia M, Alamri A, Parine NR, Alhadheq A, Basavarajappa S, Abdullah Al-Kheraif AA, Semlali A (2016). “Effect of smoking on the genetic makeup of toll-like receptors 2 and 6.” Onco Targets and Therapy. Vol. 9, pages 7187-7198. https://doi.org/10.2147/OTT.S109650
  40. Semlali A, Reddy Parine N, Arafah M, Mansour L, Azzi A, Al Shahrani O, Al Amri A, Shaik JP, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Kohailan M, Rouabhia M, Alanazi MS (2016).  “Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.” PLoS One. vol. 11, (1):e0146333. https://doi.org/10.1371/journal.pone.0146333
  41. Alharbi IA, Rouabhia M (2016). “Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression.” Journal of Periodontal Research.  Vol. 51, (No. 5) pages 630-638. https://doi.org/10.1111/jre.12343
  42. Derradjia A, Alanazi H, Park HJ, Djeribi R, Semlali A, Rouabhia M (2016). “α-tocopherol decreases interleukin-1β and -6 and increases human β-defensin-1 and -2 secretion in human gingival fibroblasts stimulated with Porphyromonas gingivalis lipopolysaccharide.” Journal of Periodontal Research. Vol. 51, (No. 3), pages 295-303. https://doi.org/10.1111/jre.12308
  43. Du Z, Bondarenko O, Wang D, Rouabhia M, Zhang Z (2016). “Ex Vivo Assay of Electrical Stimulation to Rat Sciatic Nerves: Cell Behaviors and Growth Factor Expression.” Journal of Cellular Physiology. Vol. 231, (No. 6), pages 1301-1312. https://doi.org/10.1002/jcp.25230
  44. Rouabhia M, Park HJ, Zhang Z (2016). “Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration.” Journal of Cellular Physiology. Vol. 231, (No. 8), pages 1814-1821. https://doi.org/10.1002/jcp.25289


Conférences et communications scientifiques récentes (5 dernières années)

  1. Rouabhia M. Pourquoi et comment préparer une demande au Comité d’éthique de la recherche, Midiconférence; Avril 2018, Faculté de médecine dentaire, Université Laval.
  2. Rouabhia M. Investigating the interaction between human gingival epithelial cells and electronic cigarette vapour. Workshop on Oral Health, E-Cigarettes and Marijuana, with the Federal-Provincial-Territorial Dental Working Group, November 10, 2017, Ottawa.
  3. Rouabhia M. La cigarette électronique et ses effets sur les cellules gingivales humaines. Midiconférence; Groupe de Perfectionnement Clinique et Pratique (GPCP). Mars 2017, Faculté de médecine dentaire, Université Laval.
  4. Rouabhia M. Electrical stimulation as a tool to accelerate cutaneous regeneration and wound repair. 4th International Conference on Integrative biology. July 18-20, 2016, Berlin, Germany.
  5. Rouabhia M. The active role of electrically stimulated fibroblasts in skin wound healing. 10th World Biomaterials Congress. May 17-22, 2016, Montreal, Canada.
  6. Rouabhia M. Peri‐implantitis and oral immunity. 1st African Congress of Dentistry & Implantology. Marrakech, Morocco, January 26 to 30.
  7. Rouabhia M. Repeated exposure to cigarette smoke increased gingival fibroblast proliferation, telomerase activity through the activation of cell cycle genes activity. 3rd International Summit on Integrative biology to be held during. August 04-06, 2015, Valencia, Spain.
  8. Rouabhia M. Stem cells in dentistry: Basic and clinical applications. 4th PAN Arab Endodontic Conference, Hammamet, Tunisia, October 29-31, 2015.
  9. Rouabhia M. Le fluor : un dilemme entre son efficacité contre les caries et sa dangerosité pour la santé. Les 23e Entretiens Odontologiques de la faculté de médecine dentaire de Monastir. 23-25 avril 2015. Monastir, Tunisie.
  10. Rouabhia M. Rôles des cellules épithéliales gingivales dans le contrôle des infections buccales. 1st Meeting of the Moroccan Association for Dental Research, Casablanca, 27-28 Mars, 2015.
  11. Rouabhia M. La cellulose Bactérienne: Un polymère naturel pour différentes applications. 10e Colloque du CREPEC, Le 9 décembre 2015, Montréal.

Autres activités

  • Membre régulier du Groupe de recherche en écologie buccale
  • Membre régulier du Réseau de la recherche en santé buccodentaire et osseuse
  • Membre de l’axe Infectiologie du CRCHUL
  • Chercheur associé au CRSFA
  • Directeur et co-directeur de plusieurs étudiants inscrits à la maîtrise en sciences dentaires et au doctorat, de même que responsable de la supervision de professionnels de recherche et de stagiaires.