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Abdelhabib Semlali

Le docteur Abdelhabib Semlali

Professeur adjoint
Discipline : Biologie cellulaire et moléculaire

Pavillon de Médecine dentaire, local 1758
418 656-2131, poste 400062
abdelhabib.semlali@greb.ulaval.ca

Formation universitaire

Post-doctorat en biologie cellulaire et moléculaire, Groupe de recherche en écologie buccale (GREB), Faculté de médecine dentaire, Université Laval 2011
Post-doctorat en biologie cellulaire et moléculaire, Institut de cardiologie et de pneumologie de Québec 2009
PhD en endocrinologie cellulaire et moléculaire, Faculté de médecine, Université de Montpellier 1, France 2003
Maîtrise en endocrinologie cellulaire et moléculaire, Faculté de médecine, La Timone-Marseille, France 1997
A.E.S.A (Attestation d’études supérieures approfondies) en biologie structurale et microbiologie, Université de Luminy, Marseille, France 1996
Diplôme universitaire en immunologie, Faculté de pharmacie de Montpellier, France 1995
Baccalauréat en biologie végétale option biochimie, Université sidi Mohamed Ibn Abdellah, FES, Maroc 1993

Spécialité clinique et projets de recherche

Cancer de la bouche : Étude des voix de signalisation cellulaire et de la Variation génétique et épigénétiques impliquées dans le Cancer de la bouche
Mécanismes cellulaires et moléculaires de l’inflammation de la cavité buccale
Lien entre Immunité innée et le développement de cancer de la bouche
Phytothérapie et traitement du cancer de la bouche


Publications récentes (5 dernières années)

  1. Abdulaziz Alghamdi, Waseem Saeed, Abdel-Basit Al-Odayni, Fahad Alharthi, Abdelhabib Semlali, Taieb Aouak. Poly(ethylene-co-vinylalcohol)/Poly(δ-Valerolactone)/Aspirin Composite: Model for New Drug-Carrier System. Polymers  05 March 2019
  2. Abutaha N, Nasr FA, Mohammed AZ, Semlali A, Al-Mekhlafi FA, Wadaan MA.Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines. Mol Biol Rep. 2019 Feb 11
  3. Mikhlid Almutairi, Abdullah M Alhadeq, Rafa Almeer, Mohammed Almutairi, Mohammed Alzahrani and Abdelhabib Semlali. Effect of the TDG rs4135050 variant on Saudi smoker population. Molecular Genetics & Genomic Medicine Feb 2019.
  4. Alanazi H, Semlali A, Chmielewski W, Rouabhia M. E-Cigarettes Increase Candida albicans Growth and Modulate its Interaction with Gingival Epithelial Cells. Int J Environ Res Public Health. 2019 Jan 21;16(2)
  5. Abdel Halim Harrath, Abdulkarem Alrezaki, Saleh H. Alwasel and Abdelhabib Semlali. Intergenerational response of steroidogenesisrelated genes to maternal malnutrition. Journal of Developmental Origins of Health and Disease 2019 Feb 21:1-8.
  6. Mikhlid Almutairi and Abdelhabib Semlali. Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development. Genetics and Molecular Research journal. 05 Jan 2019  
  7. SemlaliA, Parine NR, Al-Numair NS, Almutairi M, Hawsawi YM, Amri AA, Aljebreen AM, Arafah M, Almadi MA, Azzam NA, Alharbi O, Alanazi MS. Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population. Onco Targets Ther. 2018 Nov 14
  8. Semlali A, Almutairi M, Rouabhia M, Reddy Parine N, Al Amri A, S Al-Numair N, M Hawsawi Y, Saud Alanazi M. Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population. PLoS One. 2018 Nov 2;13(11)
  9. Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali. Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer. Genetics and Molecular Research journal. 05 Nov 2018
  10. Chapitre : Abdelhabib Semlali, Rawan Alnemari, Esraa Almalki,Reem Alrashed and Mohammed Alanazi. Toll-Like Receptors Gene Polymorphism and Susceptibility to Cancer Development. Intechopen. October 2018
  11. Alghamdi AA, Alsolami A, Saeed WS, Al-Odayni AM, SemlaliA, Aouak T. Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system. Des Monomers Polym. 2018 Sep 22
  12. Alanazi H, Park HJ, Chakir J, Semlali A, Rouabhia M. Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis. Food Chem Toxicol. 2018 Aug
  13. Waseem Sharaf Saeed, Abdel-Basit Al-Odayni, Abdulaziz Ali Alghamdi, Ahmad Abdulaziz, Al-Owais, Abdelhabib Semlali and Taieb Aouak. Miscibility of Poly(Ethylene-co Vinylalcohol) /Poly (δ-Valerolactone) Blend and Tissue Engineering Scaffold Fabrication Using Naphthalene as Porogen. Polymer-Plastics Technology and Engineering,28 May 2018
  14. Abdulaziz Ali Alghamdi, Abdulillah Al-Soulami, Wassem Sharaf Saeed, Abdel- Basit Al-Odayni, Abdelhabib Elsamlali, Ahmed Abdulaziz Al-Owaais & Taieb Aouak. Grafting of sulfamethoxazole on acrylic acid –vinyl- methyl ketone copolymer using the Schiff base reaction−application as a drug delivery system. International journal of polymeric materials and polymeric biomaterials, March 2018
  15. Metwally DM, Al-Olayan EM, Alanazi M, Alzahrany SB, Semlali Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of  praziquantel in vivo. BMC Complement Altern Med. 2018 Apr 27
  16. Al-Tamimi J, SemlaliA, Hassan I, Ebaid H, Alhazza IM, Mehdi SH, Al-Khalifa M, Alanazi MS. Samsum Ant Venom Exerts Anticancer Activity Through Immunomodulation In Vitro and In Vivo. Cancer Biother Radiopharm. 2018 Mar;33(2)
  17. Abutaha N, SemlaliA, Baabbad A, Al-Shami M, Alanazi M, Wadaan MA. Anti-proliferative and anti-inflammatory activities of entophytic Penicillium crustosum from Phoenix dactylifer. Pak J Pharm Sci. 2018 Mar;31(2)
  18. Belmadani A, SemlaliA, Rouabhia M. Dermaseptin-S1 decreases C. albicans growth, biofilm formation and the expression of hyphal wall protein 1 and aspartic proteases genes. J Appl Microbiol. 2018 Feb
  19. Park HJ, Salem M, SemlaliA, Leung KP, Rouabhia M. Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro. Peptides. 2017 Jul
  20. SemlaliA, Almutairi M, Parine NR, Al Amri A, Shaik JP, Al Naeem A, Abdulla Ajaj S, Rouabhia M, Alanazi MS . No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations. Onco Targets Ther. 2017 Apr 27
  21.  Park HJ, Salem M, Semlali A, Leung KP, Rouabhia M. Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro. Peptides. 2017 May 10
  22. Harrath AH, Semlali A, Mansour L, Aldahmash W, Omar SYA, Anazi MSA, Nyengaard JR, Alwasel S. Dynamics of Cytokine-like Activity in the Hyperplasic Ovary of Ex-fissiparous Planarians. Biol Bull. 2017 Feb;232(1)
  23. Semlali A, Jalouli M, Parine NR, Al Amri A, Arafah M, Al Naeem A, Abdullah Ajaj S, Rouabhia M, Alanazi MS. Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women. Onco Targets Ther. 2017 Feb
  24. Kohailan M, Alanazi M, Rouabhia M, Al Amri A, Parine NR,Semlali  Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia Onco Targets Ther. 2017 Feb 9
  25. Kohailan M, Alanazi M, Rouabhia M, Alamri A, Parine NR, Alhadheq A, Basavarajappa S, Abdullah Al-Kheraif AA,Semlali  Effect of smoking on the genetic makeup of toll-like receptors 2 and 6. Onco Targets Ther. 2016 Nov
  26. Rouabhia M, Park HJ,Semlali A, Zakrzewski A, Chmielewski W, Chakir J. E-Cigarette Vapor Induces an Apoptotic Response in Human Gingival Epithelial Cells Through the Caspase-3 Pathway. J Cell Physiol. 2017 
  27. SemlaliA, Parine NR, Al Amri A, Azzi A, Arafah M, Kohailan M, Shaik JP, Almadi MA, Aljebreen AM, Alharbi O, Ali Azzam N, Rouabhia M, Alanazi MS.Association between TLR 9 polymorphisms and colon cancer susceptibility in Saudi Arabian female patients. Onco Targets Ther. 2016 Dec 
  28. Alhadheq AM, Purusottapatnam Shaik J, Alamri A, Aljebreen AM, Alharbi O, Almadi MA, Alhadeq F, Azzam NA,Semlali A, Alanazi M, Bazzi MD, Reddy Parine N. The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3’Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. Dis Markers. 2016
  29. SemlaliA, Reddy Parine N, Arafah M, Mansour L, Azzi A, Al Shahrani O, Al Amri A, Shaik JP, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Kohailan M, Rouabhia M, Alanazi MS. Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients. PLoS One. 2016 Jan 15
  30. Abdelhabib Semlali, Abdullah Al Amri, Arezki Azzi, Omair Al Shahrani, Maha Arafah, Mohammad Kohailan, Abdulrahman M Aljebreen, Othman alharbi, Majid A Almadi, Nahla Ali Azzam, Narasimha Reddy Parine, Mahmoud Rouabhia and Mohammad Alanazi.. Expression and new exon mutations of the human beta defensins and their association on colon cancer development Plos one 2015
  31. Alanazi H,Semlali A, Perraud L, Chmielewski W, Zakrzewski A, Rouabhia M. Cigarette Smoke-Exposed Candida albicans Increased Chitin Production and Modulated Human Fibroblast Cell Responses. Biomed Res Int. 2014.
  32. Alamri A, Semlali A, Jacques E, Alanazi M, Zakrzewski A, Chmielewski W, Rouabhia M. Long-term exposure of human gingival fibroblasts to cigarette smoke condensate reduces cell growth by modulating Bax, caspase-3 and p53 expression. J Periodontal Res. 2014 Aug 19.
  33. Harrath AH, Semlali A, Mansour L, Ahmed M, Sirotkin AV, Al Omar SY, Arfah M, Al Anazi MS, Alhazza IM, Nyengaard JR, Alwasel S. Infertility in the hyperplasic ovary of freshwater planarians: the role of programmed cell death. Cell Tissue Res. 2014 Aug 9
  34. Semlali A, Killer K, Alanazi H, Chmielewski W, Rouabhia M. Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1, HWP1 and SAP2 gene expression. BMC Microbiol. 2014 Mar 12
  35. Abutaha NaelAl-mekhlafi Fahd A., Semlali Abdelhabib, Baabbad Almohannad and Wadaan Mohammed A.  Aspergillus sydowi Metabolites Efficacies against the Mosquito Larval (Culexpipiens and Aedescaspius) Population and Cytotoxicity after Purification with Column ChromatographyRESEARCH JOURNAL OF BIOTECHNOLOGY (2014). 9(1)

 


Conférences et communications scientifiques récentes (5 dernières années)

  1. Esraa Almalki, Abdelilah Aboussekhra, Abdullah Al Amriand Abdelhabib Semlali. Effect of Curcumin Analog PAC on the DNA Repair Pathway Gene Expression in Human Breast Cancer Cells. The Gordon Research Conference on Quantitative Genetics and Genomic, Italy, 10-15 February 2019
  2. Reem Al-Rashed and Abdelhabib Semlali. Anti- Cancer effect of Anethole: Targeting specific EGFR pathway inhibition in breast cancer.The 4th Annual Meeting Conference of Saudi Society of Clinical Chemistry held in Riyadh, 4th – 6th December 2018.
  3. Esraa Almalki, Abdelilah Aboussekhra, Abdullah Al Amriand Abdelhabib Semlali. Assessing the Anti-Carcinogenic Effect of Curcumin Analog PAC by Modulating the DNA Repair Pathway Gene Expression in Breast Cancer Cells. The 4thSaudi Society for Clinical Chemistry Annual Conference, Riyadh, 4-6 December 2018.
  4. Reem Alrashed and Abdelhabib Effect of Anethole on the Physiological Responses by Modulating Specific EGFR Pathways in Human Breast Cancer Cells. Advances in Breast Cancer Research, Riyadh, 7th – 8th November, King Faisal Specialist Hospital & Research Center.
  5. Esraa Almalki, Abdelilah Aboussekhra, Abdullah Al Amriand Abdelhabib Semlali. Assessing the Anti-Carcinogenic Effect of Curcumin Analog PAC by Modulating the DNA Repair Pathway Gene Expression in Breast Cancer Cells. The 9thKAIMRC Annual Forum for Medical Research conference, king Abdullah international medical research center, Riyadh, 26-28 November 2018
  6. Esraa Almalki, Abdelilah Aboussekhra, Abdullah Al Amriand Abdelhabib Semlali. Assessing the Anti-Carcinogenic Effect of Curcumin Analog PAC by Modulating the DNA Repair Pathway Gene Expression in Breast Cancer Cells. Advances in the Breast Cancer Research conference, king Faisal specialist hospital and research center, Riyadh, 7-8 November 2018.
  7. Rawan Al-Nemari, Abdulrahman Al-Senaidy and Abdelhabib Semlali.. In vitro and vivo Studies for Assessing the Anti-Proliferative, Anti-Migration and Apoptotic Activity of A. squamosa L. Leaves Extract. 20th International Conference on Cancer Stem Cells and Metastatic Growth , Dubai, UAE January, 22-23, 2018.
  8. Abdelhabib Semlali, Abdullah Al Amri, Arezki Azzi, Maha Arafah, Abdulrahman M Aljebreen, Othman alharbi, Majid A Almadi, Nahla Ali Azzam and Mohammad Alanazi. Critical association between the deregulation of the epigenetic modifications of the human beta defensins and colon cancer: Expression, new mutations, pattern distribution and function. The 11th Congress of the World Federation of Nuclear Medicine and Biology, August 27 – 31, 2014, Cancún, México.
  9. Abdelhabib Semlali, Abdullah Al Amri, Arezki Azzi, Maha Arafah, Abdulrahman M Aljebreen, Othman alharbi, Majid A Almadi, Nahla Ali Azzam and Mohammad Alanazi. Critical association between the deregulation of the epigenetic modifications of human beta defensins and colon cancer: Expression, new mutation, pattern, distribution and function .16 TH International Congress for Hormonal Steroids and Hormones &cancer,2.3.4 December 2014, Riyadh, Saudi arabia.
  10. Abdelhabib Semlali, NarasimhaReddy Parine, Omair Al Shahrani, Abdullah Al Amri, Maha Arafah, Majid A Almadi, Abdulrahman M Aljebreen, Othman alharbi, Nahla Ali Azzam, Mahmoud Rouabhia and Mohammad Alanazi. Susceptibility to colon cancer development is associated with Toll-like Receptor 2 (TLR2) polymorphisms resulting in a lack TLR2 gene expression.16 TH International Congress for Hormonal Steroids and Hormones &cancer,2.3.4 December 2014, Riyadh, Saudi arabia.
  11. Abdelhabib Semlali, Omair Al Shahrani, Muhammed Kohailan and Mohammad Alanazi. TGF beta 1 and IL-1 synergically modulate IL-6 and Il-8 expression release in colon cancer cells through ERK1/2,p38,JNK and NFkB pathways. The role of dexametasone treatment.16 TH International Congress for Hormonal Steroids and Hormones &cancer,2.3.4 December 2014, Riyadh, Saudi arabia.

Autres activités

Membre régulier du Réseau de la recherche en santé buccodentaire et osseuse
Membre régulier du Groupe de recherche en écologie buccale