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Mahmoud Rouabhia

docteur Rouabhia

Professeur titulaire
Discipline : immunologie buccale et pathologie buccales, biomatériaux

Pavillon de médecine dentaire, local 1728
418 656-2131, poste 416321
mahmoud.rouabhia@fmd.ulaval.ca

Formation universitaire

Post doctorat en Immunologie/inflammation, Dalhousie University Canada 1989
Doctorat en Immuno-physiologie Faculté des sciences, Université de Limoges, France 1988
Maîtrise en biologie cellulaire et moléculaire Faculté des sciences, Université de Limoges, France 1985
Maîtrise en biologie cellulaire et moléculaire Faculté des sciences, Université de Limoges, France

Spécialité clinique et projets de recherche

  • Investigate C. albicans and S. mutans passage through the EHOM following treatment with two Oasis products
  • Étudier le lien entre la fumée de cigarette et le cancer buccal
  • Electrically conductive biodegradable polymers for tissue engineering
  • Effet de la stimulation électrique sur la cicatrisation
  • Évaluer l’effet de la fumée de cigarette sur la croissance des cellules gingivales
  • Étudier l’effet des facteurs de croissance sur la régénération osseuse in vitro
  • Étudier les interactions entre l’hôte et les microorganismes
  • Identification of early phase C. albicans biofilm proteins
  • Efficacité d’un nouveau peptide anti-microbien sur la virulence de Candida albicans

Publications récentes (5 dernières années)

  1. Mao J**, Rouabhia M and Zhang Z (2019). Surface modification by assembling: a modular approach based on the match in nanostructures. J. Mater. Chem. B, 7, 755-762. http://dx.doi.org.acces.bibl.ulaval.ca/10.1039/C8TB02789G.
  2. Alanazi H*, Semlali A, Chmielewski W, Rouabhia M. (2019). E-Cigarettes Increase Candida albicans Growth and Modulate its Interaction with Gingival Epithelial Cells. Int J Environ Res Public Health. 2019 Jan 21;16(2).
  3. Benzaid C*, Belmadani A*, Djeribi R and Rouabhia M. (2019). The Effects of Mentha × piperita Essential Oil on C. albicans Growth, Transition, Biofilm Formation, and the Expression of Secreted Aspartyl Proteinases Genes Antibiotics 2019, 8(1), 10; https://doi.org/10.3390/antibiotics8010010.
  4. Rouabhia M, Mighri N*, Mao J, Park H-J*, Mighri F, Ajji A, Zhang Z. (2018). Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation. Can J Chem Eng. 96; 2236-2242.
  5. Semlali A, Almutairi M, Rouabhia M, Reddy Parine N, Al Amri A, S Al-Numair N, M Hawsawi Y, Saud Alanazi M. (2018) Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population. PLoS One. 2018 Nov 2;13(11):e0203376.
  6. Rouabhia M, Alanazi H*, Park HJ*, Gonçalves RB. (2018). Cigarette smoke and e-cigarette vapor dysregulate osteoblast interaction with titanium dental implant surface. J Oral Implantol. 2018 Aug 30. doi: 10.1563/aaid-joi-D-18-00009.
  7. Alanazi H*, Park HJ, Chakir J, Semlali A, Rouabhia M. Comparative study of the effects of cigarette smoke and electronic cigarettes on human gingival fibroblast proliferation, migration and apoptosis. (2018). Food Chem Toxicol. May 22;118:390-398. doi: 10.1016/j.fct.2018.05.049.
  8. Belmadani A*, Semlali A, Rouabhia M. (2018). Dermaseptin-S1 decreases Candida albicans growth, biofilm formation and the expression of hyphal wall protein 1 and aspartic protease genes. J Appl Microbiol, 125 (1), p. 72-83, 2018, ISSN: 1364-5072.
  9. Salem IH**, Plante S, Gounni AS, Rouabhia M, Chakir J. A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process. Cell Signal, 43, p. 47-54, 2018, ISSN: 0898-6568.
  10. Haj-Salem I**, Plante S, Gounni AS, Rouabhia M, Chakir J. (2018). Fibroblast-derived exosomes promote epithelial cell proliferation through TGF-β2 signalling pathway in severe asthma. Allergy, 73 (1), p. 178-186.
  11. Mao J**, Li C, Park HJ, Rouabhia M, Zhang Z. Conductive Polymer Waving in Liquid Nitrogen ACS Nano, 11 (10), p. 10409-10416, 2017.
  12. Rouabhia M, Rouabhia D*, Park HJ*, Giasson L, Zhang Z. Effect of soft foods on primary human gingival epithelial cell growth and the wound healing process. Food Res Int, 100 (Pt 1), p. 433-441, 2017.
  13. Park HJ*, Salem M*, Semlali A, Leung KP, Rouabhia M. Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro. Peptides, 93, p. 33-43, 2017.
  14. Rouabhia M, Park HJ*, Semlali A, Zakrzewski A, Chmielewski W, Chakir J. E-cigarette vapor induces an apoptotic response in human gingival epithelial cells through the caspase-3 pathway. J Cell Physiol, 232 (6), p. 1539-1547, 2017.
  15. Wang Y**, Rouabhia M, Lavertu D, Zhang Z. Pulsed electrical stimulation modulates fibroblasts’ behavior through the Smad signalling pathway. J Tissue Eng Regen Med, 11 (4), p. 1110-1121, 2017.
  16. Semlali A, Parine NR, Al Amri A, Azzi A, Arafah M, Kohailan M, Shaik JP, Almadi MA, Aljebreen AM, Alharbi O, Ali Azzam N, Rouabhia M, Alanazi MS. Association between TLR-9 polymorphisms and colon cancer susceptibility in Saudi Arabian female patients. Onco Targets Ther, 10 , p. 1-11, 2017.
  17. Kohailan M**, Alanazi M, Rouabhia M, Al Amri A, Parine NR, Semlali A. Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia. Onco Targets Ther, 10 , p. 745- 752, 2017.
  18. Semlali A, Jalouli M, Parine NR, Al Amri A, Arafah M, Al Naeem A, Abdullah Ajaj S, Rouabhia M, Alanazi MS. Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative breast cancer in Saudi women. Onco Targets Ther, 10, p. 1207-1216, 2017.
  19. Semlali A, Almutairi M, Parine NR, Al Amri A, Shaik JP, Al Naeem A, Abdulla Ajaj S, Rouabhia M, Alanazi MS. No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations. Onco Targets Ther, 10, p. 2325-2333, 2017.
  20. Bakopoulou A, Huang GT, Rouabhia M, Geurtsen W, About I. Advances and New Technologies towards Clinical Application of Oral Stem Cells and Their Secretome. Stem Cells Int, 2017, p. 6367375, 2017.
  21. Wang Y**, Rouabhia M, Zhang Z (2016). Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGFβ1/ERK/NF-κB axis. Biochim Biophys Acta. 2016 Jul; 1860(7):1551-9.
  22. Semlali A, Parine NR, Al Amri A, Azzi A, Arafah M, Kohailan M, Shaik JP, Almadi MA, Aljebreen AM, Alharbi O, Ali Azzam N, Rouabhia M, Alanazi MS. Association between TLR-9 polumorphisms and colon cancer susceptibility in Saudi Arabian female patients. Onco Targets Ther. 2016 Dec 16;10:1-11.
  23. Kohailan M**, Alanazi M, Rouabhia M, Alamri A, Parine NR, Alhadheq A, Basavarajappa S, Abdullah Al-Kheraif AA, Semlali A (2016). Effect of smoking on the genetic makeup of toll-like receptors 2 and 6. Onco Targets and Therapy 9:7187-7198.
  24. Semlali A, Reddy Parine N, Arafah M, Mansour L, Azzi A, Al Shahrani O, Al Amri A, Shaik JP, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Kohailan M, Rouabhia M, Alanazi MS (2016). Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients. PLoS One 11(1):e0146333 (19p).
  25. Alharbi IA*, Rouabhia M (2016). Repeated exposure to whole cigarette smoke promotes primary human gingival epithelial cell growth and modulates keratin expression. Journal of Periodontal Research 51:630-638.
  26. Derradjia A*, Alanazi H*, Park HJ*, Djeribi R, Semlali A, Rouabhia M (2016). α-tocopherol decreases interleukin-1β and -6 and increases human β-defensin-1 and -2 secretion in human gingival fibroblasts stimulated with Porphyromonas gingivalis lipopolysaccharide. Journal of Periodontal Research 51:295-303.
  27. Du Z**, Bondarenko O, Wang D, Rouabhia M, Zhang Z (2016). Ex Vivo Assay of Electrical Stimulation to Rat Sciatic Nerves: Cell Behaviors and Growth Factor Expression. Journal of Cellular Physiology 231:1301-1312.
  28. Rouabhia M, Park HJ*, Zhang Z (2016). Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration. Journal of Cellular Physiology 231:1814-1821.
  29. Mighri N*, Mao J**, Mighri F, Ajji A, Rouabhia M. Chitosan-Coated Collagen Membranes Promote Chondrocyte Adhesion, Growth, and Interleukin-6 Secretion. Materials (Basel). 2015 Nov 13;8 (11):7673-7689.
  30. Alamri A*, Semlali A, Jacques É, Alanazi M, Zakrzewski A, Chmielewski W, Rouabhia M (2015). Long-term exposure of human gingival fibroblasts to cigarette smoke condensate reduces cell growth by modulating Bax, caspase-3 and p53 expression. Journal of Periodontal Research 50:423-433.
  31. Niu X**, Rouabhia M, Chiffot N**, King MW, Zhang Z (2015). An electrically conductive 3D scaffold based on a nonwoven web of poly(L-lactic acid) and conductive poly(3,4-ethylenedioxythiophene). J Biomed Mater Res A. 2015 Aug;103(8):2635-44.
  32. Park HJ*, Rouabhia M, Lavertu D, Zhang Z (2015). Electrical Stimulation Modulates the Expression of Multiple Wound Healing Genes in Primary Human Dermal Fibroblasts. Tissue Engineering Part A 21(13-14):1982-1990.
  33. Rouabhia M (2015). Advantages and Limitations of Oral Stem Cell use for Oral Tissue Replacement. Journal of Oral Biology 2:9 (9p).
  34. Semlali A, Al Amri A*, Azzi A, Al Shahrani O, Arafah M, Kohailan M, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Parine NR, Rouabhia M, Alanazi MS (2015). Expression and new exon mutations of the human Beta defensins and their association on colon cancer development. PLoS One 10(6):e0126868 (16p).
  35. Wang Y**, Rouabhia M, Lavertu D, Zhang Z (2015). Pulsed electrical stimulation modulates fibroblasts’ behaviour through the Smad signalling pathway. J Tissue Eng Regen Med. 2017 Apr;11(4):1110-1121.

Conférences et communications scientifiques récentes (5 dernières années)

  1. Rouabhia M. Pourquoi et comment préparer une demande au Comité d’éthique de la recherche, Midiconférence; Avril 2018, Faculté de médecine dentaire, Université Laval.
  2. Rouabhia M. Investigating the interaction between human gingival epithelial cells and electronic cigarette vapour. Workshop on Oral Health, E-Cigarettes and Marijuana, with the Federal-Provincial-Territorial Dental Working Group, November 10, 2017, Ottawa.
  3. Rouabhia M. La cigarette électronique et ses effets sur les cellules gingivales humaines. Midiconférence; Groupe de Perfectionnement Clinique et Pratique (GPCP). Mars 2017, Faculté de médecine dentaire, Université Laval.
  4. Rouabhia M. Electrical stimulation as a tool to accelerate cutaneous regeneration and wound repair. 4th International Conference on Integrative biology. July 18-20, 2016, Berlin, Germany.
  5. Rouabhia M. The active role of electrically stimulated fibroblasts in skin wound healing. 10th World Biomaterials Congress. May 17-22, 2016, Montreal, Canada.
  6. Rouabhia M. Peri‐implantitis and oral immunity. 1st African Congress of Dentistry & Implantology. Marrakech, Morocco, January 26 to 30.
  7. Rouabhia M. Repeated exposure to cigarette smoke increased gingival fibroblast proliferation, telomerase activity through the activation of cell cycle genes activity. 3rd International Summit on Integrative biology to be held during. August 04-06, 2015, Valencia, Spain.
  8. Rouabhia M. Stem cells in dentistry: Basic and clinical applications. 4th PAN Arab Endodontic Conference, Hammamet, Tunisia, October 29-31, 2015.
  9. Rouabhia M. Le fluor : un dilemme entre son efficacité contre les caries et sa dangerosité pour la santé. Les 23e Entretiens Odontologiques de la faculté de médecine dentaire de Monastir. 23-25 avril 2015. Monastir, Tunisie.
  10. Rouabhia M. Rôles des cellules épithéliales gingivales dans le contrôle des infections buccales. 1st Meeting of the Moroccan Association for Dental Research, Casablanca, 27-28 Mars, 2015.
  11. Rouabhia M. La cellulose Bactérienne: Un polymère naturel pour différentes applications. 10e Colloque du CREPEC, Le 9 décembre 2015, Montréal.

Autres activités

  • Membre régulier du Groupe de recherche en écologie buccale
  • Membre régulier du Réseau de la recherche en santé buccodentaire et osseuse
  • Membre de l’axe Infectiologie du CRCHUL
  • Chercheur associé au CRSFA
  • Directeur et co-directeur de plusieurs étudiants inscrits à la maîtrise en sciences dentaires et au doctorat, de même que responsable de la supervision de professionnels de recherche et de stagiaires.